There are many conditions that produce weakness and can lead to knuckling or dragging of the front and hind paws and limbs. Conditions that can affect the hind legs include degenerative myelopathy (DM), sciatic nerve injury, disc disease, and spinal cord injury. Brachial plexus and radial nerve injuries can cause front paw knuckling or limb dragging. A fibrocartilaginous embolism (FCE) can affect either...