Love, Actually: How a Tiny Peptide Drives Passion for Dogs

Love, Actually: How a Tiny Peptide Drives Passion for Dogs

Love, Actually: How a Tiny Peptide Drives Passion for Dogs

Oxytocin. Most of us think of it as the hormone that helps bitches whelp and produce milk. And yes, it’s that, but so much more. A series of recent studies have revealed how oxytocin has a major effect on the brains of both people and dogs to strengthen the human-canine bond that indescribable interspecies attachment that might just explain why you’re reading this.

Oxytocin is a peptide hormone that is secreted into the blood from the pituitary, a pea-sized structure at the base of the brain, although it also can be made in many other cells of the body. Its size just 9 amino acids long truly belies its important role in how people and dogs respond to the world around them.

Oxytocin plays an important role in human communication. When a mother gazes at her infant, attachment begins to develop. You may be familiar with imprinting, in which an orphan baby duck becomes attached to a human and begin to follow it around. Human attachment is a more sophisticated version of this phenomenon, and is the basis of interpersonal relationships.

Oxytocin plays other roles in humans as well – it’s called the “love hormone” for a reason. Oxytocin makes you feel good when you’re with someone you love by stimulating the reward center in your brain, and it also reduces stress (1, 2).

Recently scientists have been studying the role of oxytocin in the human-canine bond. It was already known that interactions between humans and dogs resulted in oxytocin release into the blood stream of both species (3). To understand more about the mechanism of this mutual hormonal response, researchers performed experiments to ask the following questions: Is gaze important for mutual oxytocin release between humans and dogs like it is for mothers and infants? And does mutual oxytocin release happen between humans and hand-raised wolves or just with dogs?


To answer these questions, researchers measured urine oxytocin levels in dogs or hand-raised wolves and their people before and after spending 30 minutes alone in a room together (4). During that time, the owners could gaze at the dogs or wolves, talk to them and touch them.

Results: Dogs differed in the amount of time that they would gaze at their owners; they were divided into long gazers and short gazers. Long gazers induced significantly higher mutual oxytocin levels in both the people and themselves during the 30-minute interaction, whereas short gazers and wolves did not.

Conclusion: As in the relationship between mother and child, humans interacting with dogs experience gaze-induced mutual oxytocin secretion and the longer the gaze, the higher the resulting oxytocin levels in both humans and dogs (and the better both feel). This hormonal interaction is called the oxytocin-gaze positive loop (we’ll refer to it as the OGPL for short). This diagram illustrates that steps that are involved in this positive feedback loop:


The Oxytocin-Gaze Positive Loop

Try a little experiment now? Sit down and gaze into your dog’s admiring eyes. Now think about how it makes you feel. It might seem silly, but just go ahead and do it. When you think about your feelings, do the words “calm,” “love,” “peaceful,” “happy,” and/or “content” come to mind? If they do, then you are experiencing the OGPL loop!

As a dog lover, I am sure that you can connect with the closing statements in the researchers’ publication:These results suggest that humans may feel affection for their companion dogs similar to that felt toward human family members...” You can’t help it – it’s a chemical attraction!



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Thank you for this article! I have a question: how does a dog discern between being looked at with love and a threatening or stimulating (good or bad) look? For example, my dog is highly exuberant around people, so I ask them not to look at him (until he calms down) because even eye contact gets him wound up. Or are dogs like us and pretty good and telling the difference?
Thanks so much!

Ann Holland

I experience this constantly with my 3 GSDs. However, my 4 year old, who was trained for it, makes strong, sustained eye contact. Another one – a rescue who was never abused – is still uncomfortable with eye contact. My 14 year old is mostly blind but still watches me closely. As for me, God loaded me with oxytocin. I have been in love with dogs since infancy.

Cathy Taylor

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